Beamline X ‐ray Source GU 8.3.1 super bend 0.25 1 1 1 12.3.1 super bend 0.25 1 1 1 SSRL 666 BL7‐1 wiggler 1 1 1 1 BL9‐1 wiggler 1 1 1 1 BL9‐2 wiggler 1 1

pressure CO2-brine core flooding at the X-ray microtomography beamline of the Advanced Light Source (ALS -Beamline 8.3.1) at Lawrence Berkeley National  

Synchrotron: ALS (Advanced Light Source) Files: Datasets (215) 10167_1_###.img (project: TM1154_1vl1) 10167_2_###.img (project: TM1154_1vl1) Beamline 8.3.1 Schedule. January 2004: February 2004: March 2004: April 2004 BLU-ICE/DCS control system on 8.3.1/12.3.1 This page outlines all the programs involved in beamline control for the LBL installation of BLU-ICE/DCS. Links to vendors are provided on the left and example log output is provided on the right. The locally-available command-line utilities will interface with this system as well as a few others. Beamline 8.3.1 PRT organization Funding Hardware Safety management Control system Scientific productivity Safety Management • Hardware safety systems • Training • Safety through simplicity • Failsafe envelope • Examples: • Liquid nitrogen – better tools • Automatic retraction – eliminate confusion • Automatic backup – eliminate distraction We thank James Holton for his assistance at the Advanced Light Source Beamline 8.3.1, which was supported by National Institutes of Health (NIH) Grant GM074929 (to R.M.S.). This work was supported by NIH Grant GM24485 (to R.M.S.) and by NIH Roadmap Center Grant P50 GM073210.

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2009-05-05 Chain: A Length: 163 amino acids Theoretical weight: 19.54 KDa Source organism: Drosophila melanogaster Expression system: Escherichia coli BL21(DE3) UniProt: Canonical: P29617 (Residues: 1541-1703; Coverage: 10%) Gene names: CG17228, pros Structure domains: Homeo-prospero domain 4xui: Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. 6p8e: p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Beamline Engineering Andrew Broadbent, NSLS-II Beamlines & Interfaces Manager Mary Carlucci-Dayton, NSLS-II Beamline Engineering Group Leader Edwin Haas, NSLS-II Sr. Project Engineer Scientific Staff Andrei Fluerasu, CHX Beamline Group Leader 8 3.1 Materials After transfer to Paratone oil (Hampton Research) and flash-freezing, diffraction data were collected at Beamline 8.3.1 (Advanced Light Source, Lawrence Berkeley National Laboratories) and processed using HKL2000 . A three-wavelength MAD experiment was performed … 2019-05-01 2b5i: Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. 4rt7: Characterizing and Overriding the Structural Mechanism of the Quizartinib-resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. 2013-03-31 1.2 Introduction to the LBNE Beamline (WBS 130.02) 2.8.3.1 Heat Loads and Heat Exchanger 2010-05-25 2010-08-27 2017-12-07 All 8.3.1 WORK The ALS mission is to advance science for the benefit of society by providing our world-class synchrotron light source capabilities and expertise to a broad scientific community. CONTACT US Beamline 8.3.1 at the Advanced Light Source is operated by the University of California Office of the President, Multicampus Research Programs and Initiatives grant MR-15-328599 the National Institutes of Health (R01 GM124149 and P30 GM124169), ALS 8.3.1 – The “TomAlberTron” Beamline 8.3.1 at the Advanced Light Source is operated by the University of California Office of the President, Multicampus Research Programs and Initiatives grant MR-15-328599 the National Institutes of Health (R01 GM124149 and P30 GM124169), Plexxikon Inc. and the Integrated Diffraction Analysis Technologies program of the US Department of Energy Office In June of 1998, BCSB staff welcomed the first research teams to Beamline 5.0.2; Beamline 5.0.1 came online in 1999, followed by Beamline 5.0.3 in 2000.

Beamline Name: 8.3.1 Primary Contact: Name: James Holton: Secondary Contact: Name: George Meigs: Owner/Operator: University of California/Plexxikon Inc/MD Anderson Cancer Research Center: Status: operational %Time Available (general use) 25: Experiments: MAD: Experiments Details "true MAD" : inverse beam and round-robin wavelength changes every

Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. High-resolution structure of the E. coli ribosome highlights rRNA and protein modifications and provides details on solvation characteristics and the structural impacts of ribosome modifications.

In addition, protein crystallography at ALS Beamline 8.3.1 yielded atomic-level close-ups of nanobody regions that directly interact with the spike. In cases where cryo-EM provided inconclusive data, the researchers relied on a relatively new technique called x-ray footprinting at ALS Beamline 3.2.1.

ALS BEAMLINE 8.3.1. (3). Example diffraction images for (A) real data collected from Gd-containing lysozyme at Advanced Light Source beamline 8.3.1, and (B) simulated diffraction   ter beamlines at the Advanced Photon Source was supported by the U.S..

Learn more. Beamline 2.0.1 – Gemini  Our new beamline, Gemini, is nearing completion, and we … 2009-11-19 The following are some useful tips for moving around x-ray data and processing in a highly platform-independent way. We begin with the "easy" tools available at 8.3.1 and then move on to a deeper explanation of how they work. The Easy Way For data collected on beamline 8.3.1 you can use these live data transfer techniques: Beamline 4.2.2: Jay Nix (JCNix@lbl.gov) Beamline 8.3.1: James Holton (JMHolton@lbl.gov) Access procedure: Access is through the ALS User Office, but please call or email the beamline scientists if you have any questions or want to discuss the feasibility of your experiment. Feature Stories on the ALS website: ALS Highlights James was honored to recognize his work in the development of the beamline 8.3.1 at the advanced light source (ALS) in the LBNL, one of the most productive beamlines, in terms of both publication number and impact, in the world.
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4rt7: Characterizing and Overriding the Structural Mechanism of the Quizartinib-resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. 2013-03-31 1.2 Introduction to the LBNE Beamline (WBS 130.02) 2.8.3.1 Heat Loads and Heat Exchanger 2010-05-25 2010-08-27 2017-12-07 All 8.3.1 WORK The ALS mission is to advance science for the benefit of society by providing our world-class synchrotron light source capabilities and expertise to a broad scientific community. CONTACT US Beamline 8.3.1 at the Advanced Light Source is operated by the University of California Office of the President, Multicampus Research Programs and Initiatives grant MR-15-328599 the National Institutes of Health (R01 GM124149 and P30 GM124169), ALS 8.3.1 – The “TomAlberTron” Beamline 8.3.1 at the Advanced Light Source is operated by the University of California Office of the President, Multicampus Research Programs and Initiatives grant MR-15-328599 the National Institutes of Health (R01 GM124149 and P30 GM124169), Plexxikon Inc. and the Integrated Diffraction Analysis Technologies program of the US Department of Energy Office In June of 1998, BCSB staff welcomed the first research teams to Beamline 5.0.2; Beamline 5.0.1 came online in 1999, followed by Beamline 5.0.3 in 2000. Beamlines 8.2.1 and 8.2.2 began operation in 2003.
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These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

ALS 8.3.1 – The “TomAlberTron” Beamline 8.3.1 at the Advanced Light Source is operated by the University of California Office of the President, Multicampus Research Programs and Initiatives grant MR-15-328599 the National Institutes of Health (R01 GM124149 and P30 GM124169), Plexxikon Inc. and the Integrated Diffraction Analysis Technologies program of the US Department of Energy Office

He is one of the most insightful proponents, designers and visionaries of synchrotron beamline development. The innovations that James has designed, built and ALS Beamline 8.3.1 is powered by a superconducting bend magnet, or “superbend,” and has experimental facilities that offer both multiple-wavelength anomalous diffraction (MAD) and In addition, protein crystallography at ALS Beamline 8.3.1 yielded atomic-level close-ups of nanobody regions that directly interact with the spike. In cases where cryo-EM provided inconclusive data, the researchers relied on a relatively new technique called x-ray footprinting at ALS Beamline 3.2.1. Beamline phone number: 510-495-2075: Recent Work at 7.3.3.

Beamline 2.0.1 – Gemini  Our new beamline, Gemini, is nearing completion, and we … 2009-11-19 The following are some useful tips for moving around x-ray data and processing in a highly platform-independent way. We begin with the "easy" tools available at 8.3.1 and then move on to a deeper explanation of how they work.